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Kinetics time course for the association (A, C, and E) and dissociation
PET probes targeting Orexin receptors
Hypocretins (orexins): The ultimate translational neuropeptides - Jacobson - 2022 - Journal of Internal Medicine - Wiley Online Library
PET images (a), AUC and SBR values (b) for the 5-HT7 receptor tracers
Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions. - Abstract - Europe PMC
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders - Bonifazi - 2023 - Medicinal Research Reviews - Wiley Online Library
Two-improved-routes-11C-PET
Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
Development of Novel 11C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Imaging
2023 Publications – Emory Radioactive Drug Discovery
Molecules, Free Full-Text
Molecules, Free Full-Text
Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain
Selective orexin receptor antagonists - ScienceDirect
Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl- 2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia