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Development of Novel 11C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Imaging

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Kinetics time course for the association (A, C, and E) and dissociation

PET probes targeting Orexin receptors

Hypocretins (orexins): The ultimate translational neuropeptides - Jacobson - 2022 - Journal of Internal Medicine - Wiley Online Library

PET images (a), AUC and SBR values (b) for the 5-HT7 receptor tracers

Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions. - Abstract - Europe PMC

Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders - Bonifazi - 2023 - Medicinal Research Reviews - Wiley Online Library

Two-improved-routes-11C-PET

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists

Development of Novel 11C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Imaging

2023 Publications – Emory Radioactive Drug Discovery

Molecules, Free Full-Text

Molecules, Free Full-Text

Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain

Selective orexin receptor antagonists - ScienceDirect

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl- 2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia