The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1
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SARM1-Dependent Axon Degeneration: Nucleotide Signaling, Neurodegenerative Disorders, Toxicity, and Therapeutic Opportunities - Helen Y. McGuinness, Weixi Gu, Yun Shi, Bostjan Kobe, Thomas Ve, 2023
NAD+ Inhibits Protein that Promotes Neuron Degeneration
Multiple domain interfaces mediate SARM1 autoinhibition
Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism - ScienceDirect
Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss
Shared TIR enzymatic functions regulate cell death and immunity across the tree of life
Structural basis for SARM1 inhibition and activation under energetic stress
A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration
Axon Biology in ALS: Mechanisms of Axon Degeneration and Prospects for Therapy
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration - ScienceDirect
Dr. Jing Yang's Lab: The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1 - IDG/McGovern Institute for Brain Research at PKU
