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Positively charged patches: tonic for CAR fitness

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Charging CAR by electrostatic power - Wang - Immunological Reviews - Wiley Online Library

Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

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Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

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Distribution of hydrophobic patches across the different Fab structural

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Both Charge-Regulation and Charge-Patch Distribution Can Drive Adsorption on the Wrong Side of the Isoelectric Point